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FDA approved opioids for chronic pain despite lacking ‘critical’ safety data, analysis finds

FDA approved opioids for chronic pain despite lacking ‘critical’ safety data, analysis finds

Health
Sept. 28 (UPI) -- The U.S. Food and Drug Administration approved nearly 50 new prescription opioid pain medications between 1997 and 2018, even though it lacked "critical" data on safety and effectiveness, an analysis published Monday by the journal Annals of Internal Medicine found. None of the 48 drugs granted agency approval during the more than 20-year period was evaluated in clinical trials that lasted longer than 12 weeks, and the trials often included narrowly defined groups of patients, researchers said. Advertisement And few included "systematic assessments" of risks associated with these medications, including addiction potential and non-medical use. "Our analysis provides a window through which to view the FDA's opioid regulation over the past 20 years," study co-author Dr. Cal...
Man City 2-5 Leicester: Pep Guardiola’s side have bigger problems than defence – Darren Fletcher analysis

Man City 2-5 Leicester: Pep Guardiola’s side have bigger problems than defence – Darren Fletcher analysis

Sports
Manchester City manager Pep Guardiola has got a lot to sort out. His side had an awful afternoon against Leicester City on Sunday and that was as poor as I've seen them play in a long time.It was more than just the fact they conceded some bad goals - what was really worrying was how lost they looked, from front to back.When things have gone wrong for City under Pep in the past, it has been easy to criticise their defence for being unable to deal with counter-attacks or for making individual mistakes.We saw both of those things happen again against Leicester, but I think the whole team has to take responsibility for this defeat - not just their defenders.The players in front of them did not put enough pressure on the ball and got played around too easily. They weren't staying with runners o...
COVID-19 underscores ‘pandemic-scale’ problem of racial inequality, analysis finds

COVID-19 underscores ‘pandemic-scale’ problem of racial inequality, analysis finds

Health
Aug. 24 (UPI) -- COVID-19 would need to kill an additional 1 million White Americans for their average life expectancy to fall to levels seen by Black Americans during non-pandemic years, an analysis published Monday by the Proceedings of the National Academy of Sciences found. The results reveal the scope of "another U.S. catastrophe" -- the "pandemic-scale problem" of racial inequality, report author Elizabeth Wrigley-Field told UPI. Advertisement "My research shows that Blacks experience a scale of extra death every year that is more than the excess deaths that Whites are likely to experience from COVID-19," said Wrigley-Field, an assistant professor of sociology at the University of Minnesota. "This gives us a metric for understanding just how severe racial inequality is, and it is as...
Lung cancer deaths in U.S. fall by up to 6% annually, analysis finds

Lung cancer deaths in U.S. fall by up to 6% annually, analysis finds

Health
Aug. 12 (UPI) -- Deaths from non-small cell lung cancer in the United States declined by about 3% a year on average between 2006 and 2016, according to an analysis published Wednesday by the New England Journal of Medicine. The number of Americans who died from the most common form of lung cancer dropped by 3.2% per year from 2006 through 2013 and by 6.3% per year from 2013 through 2016, researchers from the National Cancer Institute said. Advertisement Between 2001 and 2008, rates of non-small cell lung cancer diagnoses across the country fell by an average of 1.9% annually. Between 2008 and 2016, diagnoses nationally fell by an average of 3.1% per year, the analysis found. This marks the first time deaths caused by the disease have declined faster than its incidence, researchers said. ...
20% of U.S. women drink early in pregnancy, CDC analysis says

20% of U.S. women drink early in pregnancy, CDC analysis says

Health
Aug. 6 (UPI) -- Up to 20% of pregnant women in the United States drink during their first trimester and more than 10% admit to binge drinking during that time, according to data released Thursday by the U.S. Centers for Disease Control and Prevention. In addition, nearly 5% reported consuming alcohol at least once during the second and third trimesters, the CDC said. Advertisement Nearly 40% indicated that they also used at least one other substance -- most commonly tobacco and marijuana -- while pregnant, the agency said. "Drinking alcohol during pregnancy can cause fetal alcohol spectrum disorders, including birth defects, behavioral disorders and impaired cognitive development," CDC researchers wrote in the analysis. The study was published as part of the agency's Morbidity and Mortal...