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Tag: antifungal

Antifungal drug eliminates dormant bowel cancer cells in mice

Antifungal drug eliminates dormant bowel cancer cells in mice

Health
June 1 (UPI) -- An antifungal medication commonly prescribed to treat toenail infections helped eliminate dormant cells within bowel tumors in mice. Researchers at the Cancer Research UK Cambridge Institute found that itraconazole effectively halts the growth and progression of certain types of colorectal cancer. Their findings were published Thursday in the Journal of Experimental Medicine. "This innovative study has taken a step toward addressing one of the biggest challenges in cancer research," Dr. Greg Hannon, director of the institute, said in a press release. "Tumors are made up of many different types of cancer cells, which can evolve separately and respond to treatments differently." Colorectal cancer of the colon and rectum is the second leading cancer killer in the United Stat...
New antifungal drug combats deadly microscopic yeast

New antifungal drug combats deadly microscopic yeast

Health
Jan. 12 (UPI) -- Scientists have discovered a novel drug compound capable of combating drug-resistant yeast strains.Microscopic yeast are a menace in hospitals. The fungi can grow in the nooks and crannies of medical equipment and hospital surfaces and can cause infections in patients with weakened immune systems. For some, an infection can prove fatal.Candida auris is one of the most problematic species, as it has developed resistance to multiple antifungal drugs.Current antifungals attack yeast by puncturing the cell membranes or by blocking sterol production. The new drug works by blocking vital proteins from attaching to the yeast cell wall. In doing so, the antifungal compound disrupts the yeast's growth process and prevents the formation of drug-resistant fungal communities.The compo...