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Tag: cellular

Cellular energy route finding may improve understanding of aging, chronic disease

Cellular energy route finding may improve understanding of aging, chronic disease

Health
Jan. 7 (UPI) -- Scientists have found a cellular route for energy that could shed more light on how humans age and develop chronic diseases. Researchers from the Washington University of St. Louis have uncovered a once unknown path for nicotinamide mononucleotide, or NMN, which helps fuel the human body, according to a new study published Monday in Nature Metabolism. "To achieve such fast uptake of NMN into the tissues, we speculated that there must be a specific NMN transporter that moves NMN directly into cells, even though no one had ever seen such a thing," Shin-ichiro Imai, a professor of developmental biology at Washington University, said in a news release. For this protein highway, the researchers found that cells must create a molecular transport system. First, NMN provides energ...
Study: Chronic sinus inflammation association with cellular changes

Study: Chronic sinus inflammation association with cellular changes

Health
Aug. 23 (UPI) -- Researchers have found the source of chronic allergic inflammation in the sinus: epithelial cells that line the respiratory tract. Performing genome-wide analysis of thousands of single cells from human patients, researchers at MIT and Brigham and Women's Hospital determined why people have chronic rhinosinusitis and some develop nasal polyps. Their findings were published Wednesday in the journal Nature. Besides potentially leading to better treatment for chronic rhinosinusitis, researchers also believe the finding could help patients with chronic inflammatory diseases of barrier tissues, such as asthma, eczema, and inflammatory bowel disease. "When you look across the entire transcriptome, comparing cells from patients with different disease statuses over thousands of g...
Drugs carried in cellular 'backpacks' help destroy solid tumors in mice

Drugs carried in cellular 'backpacks' help destroy solid tumors in mice

Health
July 10 (UPI) -- Nanoparticle "backpacks" with immune-stimulating drugs successfully helped T cells destroy solid tumors in mice, researchers report. Engineers at the Massachusetts Institute of Technology who developed the method found it could enhance the T cells' activity without harmful side effects. In a study published Monday in the journal Nature Biotechnology, the researchers report that 60 percent of treated animals' tumors disappeared completely in an early test of the method. The drugs are made of a gel from molecules of cytokine IL-15 held together by a cross-linker that degrades when the T cell reaches a tumor and is activated. Nanoparticles are between 1 and 100 nanometers in size -- comparatively, a human hair is 75,000 nanometers thick. "We found you could greatly improve ...