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Gene-editing enzymes imaged in 3D

Gene-editing enzymes imaged in 3D

Science
July 8 (UPI) -- Scientists have for the first time captured high-definition, 3D images of enzymes in the process of cutting DNA strands. The breakthrough -- described Monday in the journal Nature Structural and Molecular Biology -- helped scientists see exactly how the gene-editing technology called CRISPR-Cas9 works, and could, in the future, help researchers design a more efficient and precise version of the technology. The findings could also help scientists better understand -- and eventually, treat and prevent -- diseases caused by DNA mutations, including cancer, sickle cell anemia, Tay-Sachs disease, Huntington's disease and many others. "It is exciting to be able to see at such a high level of detail how Cas9 actually works to cut and edit DNA strands," lead study author Sriram S...