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Genetic changes in blood may predict leukemia diagnosis

Genetic changes in blood may predict leukemia diagnosis

Health
July 9 (UPI) -- Studying genetic changes in blood, researchers have found a way to identify people at high risk of developing acute myeloid leukemia several years before diagnosis. In the study, published Monday in the journal Nature, researchers from around the world found changes in DNA can reveal the roots of AML in healthy people an average of 6.3 years before symptoms. The researchers hope that methods of reducing the likelihood of developing the cancer will arise with earlier detection and monitoring of those at risk of AML. "Acute myeloid leukemia often appears very suddenly in patients, so we were surprised to discover that its origins are generally detectable more than five years before the disease develops," first author Dr Grace Collord, of the Wellcome Sanger Institute and Un...
US clears breakthrough gene therapy for childhood leukemia

US clears breakthrough gene therapy for childhood leukemia

Technology
Opening a new era in cancer care, U.S. health officials on Wednesday approved a breakthrough treatment that genetically engineers patients' own blood cells into an army of assassins to seek and destroy childhood leukemia. The Food and Drug Administration called the approval historic, the first gene therapy to hit the U.S. market. Made from scratch for every patient, it's one of a wave of "living drugs" under development to fight additional blood cancers and other tumors, too.Novartis Pharmaceuticals set the price for its one-time infusion of so-called "CAR-T cells" at $ 475,000, but said there would be no charge for patients who didn't show a response within a month. "This is a brand new way of treating cancer," said Dr. Stephan Grupp of Children's Hospital of Philadelphia, who treated th...