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Chemists find better way to manipulate 3D structure of molecules

Chemists find better way to manipulate 3D structure of molecules

Science
Sept. 21 (UPI) -- Scientists have developed a more efficient and effective way to manipulate the 3D structure of molecules, a breakthrough that could improve the process of discovering and designing new drugs. The breakthrough builds on the work of chemist Akira Suzuki, who won a Nobel prize for his development of palladium-catalyzed coupling reactions. Suzuki and his research partners showed carbon atoms could be bonded using palladium catalysts. The work aided the drug discovery and synthesis process, but the method only allowed scientists to manipulate molecules in 2D. Most medical compounds involve chiral molecules, molecules that can exist in two forms -- as two mirror images, like a right hand and left hand. Often, the mirror image of a medically beneficial chiral molecule can have ...
'Molecular hopper' can transport, manipulate single strands of DNA

'Molecular hopper' can transport, manipulate single strands of DNA

Science
Aug. 31 (UPI) -- Scientists have designed a molecular machine -- a "molecular hopper" -- capable of moving single strands of DNA. The hopper moves along a nanoscale track. Its locomotion is made possible by the making and breaking of simple chemical bonds. In lab tests, the hopper successfully carried single strands of DNA through a protein nanotube. The breakthrough could inspire the next generation of gene editing technologies. "Being able to control molecular motion is the holy grail of building nanoscale machines," Hagan Bayley, a professor of chemistry at Oxford University, said in a news release. "Being able to process single molecules of DNA under precise chemical control may provide an alternative to the use of enzymes in DNA sequencing technologies, improving their speed and the ...