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Tag: mice

Exercise leads to generation of new heart cells in study with mice

Exercise leads to generation of new heart cells in study with mice

Health
April 25 (UPI) -- Researchers have figured out why exercise is good for the heart, at least in mice: It helps the organ generate more new heart muscle cells.Exercise can even deliver the benefit after a heart attack, according to researchers from the Harvard Department of Stem Cell and Regenerative Biology, Massachusetts General Hospital, Harvard Medical School and the Harvard Stem Cell Institute. The researchers, who published their findings Wednesday in the journal Nature Communications, noted that public health, physical education and the rehabilitation of cardiac patients can help prevent heart failure."We wanted to know whether there is a natural way to enhance the regenerative capacity of heart muscle cells," Dr. Ana Vujic, a researcher at Harvard, said in a press release. "So we dec...
Miniature human brain implants survive, grow inside mice for months

Miniature human brain implants survive, grow inside mice for months

Science
April 16 (UPI) -- Miniature human brains, or human brain organoids, can survive and grow after being implanted in the skulls of mice. It's the first time human cerebral organoids have been installed inside another species.Researchers describe the breakthrough in a new paper published Monday in the journal Nature Biotechnology.Scientists grew the pea-sized brains from stem cells and then placed them inside the skulls of mice. Researchers removed a small amount of tissue to make room for the miniature brains. Tiny, transparent windows in the skulls of the test mice allowed scientists to keep tabs on the brain implants -- the organoids were also designed to express a green fluorescent protein, causing them to glow inside the mice skulls.Roughly 80 percent of the implants were successfully rec...
Alzheimer's disease reversed in mice, offering hope for humans, new research shows

Alzheimer's disease reversed in mice, offering hope for humans, new research shows

Health
"Remarkable" -- that’s how researchers are describing the results of a new study done on mice displaying traits associated with Alzheimer's disease. The deletion of just a single enzyme saw the near total reversal of the deposition of amyloid plaques found in brains of those with Alzheimer's, improving cognitive functions in the mouse subjects, according to the study from researchers at the Cleveland Clinic, published Feb. 14 in the Journal of Experimental Medicine. These promising research findings center around deleting a gene that produces an enzyme called BACE1, which helps make the beta-amyloid peptides that accumulate abnormally in the brains of people with Alzheimer’s disease. Studies have shown that stopping or reducing that enzyme’s activity dramatically reduces production of b
Evidence of convergent evolution found in gene regulation of humans, mice

Evidence of convergent evolution found in gene regulation of humans, mice

Science
Jan. 18 (UPI) -- New research shows humans and mice regulate their genes in similar ways.Because many living organisms face similar problems and ecological pressures, they sometimes develop similar solutions. When species that aren't closely related evolve similar adaptations, it's called convergent evolution.A new study, published this week in the journal PNAS, presents new evidence of convergent evolution among humans and mice. The pair deploy similar mechanisms for regulating noncoding RNA, segments which aren't translated into proteins."This study highlights the importance of noncoding RNA and transposable elements in the regulation of gene expression and in the evolution of gene expression networks in mammalian genomes," Manuel Ares, professor of molecular, cell and developmental biol...
Losing weight: Manipulating a brain cell gets results in mice

Losing weight: Manipulating a brain cell gets results in mice

Health
July 28 (UPI) -- A new study has found something remarkable: The activation of a particular type of immune cell in the brain can, on its own, lead to obesity in mice. This striking result provides the strongest demonstration yet that brain inflammation may be a cause, rather than a consequence, of obesity. It also provides promising leads for new anti-obesity therapies. The evidence linking brain inflammation to obesity has been building for some time. Consistent overeating causes stress and damage to cells in the body and brain. This damage results in a response from the immune system that has a wide range of effects. Some of these effects help to reduce the problems caused by overeating, but others seem to make things worse. For example, in the hypothalamus -- the part of the brain that ...