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Tag: promising

DNA vaccine shows promising, long-term results against Ebola virus

DNA vaccine shows promising, long-term results against Ebola virus

Health
Oct. 10 (UPI) -- A synthetic DNA vaccine is showing immediate and long-term promising results against the Ebola virus in preclinical animal research. Scientists at The Wistar Institute Vaccine and Immunotherapy Centers designed optimized synthetic DNA vaccine candidates that target a virus surface protein called glycoprotein. The findings were published Wednesday in the Journal of Infectious Diseases. The Zaire Ebolavirus infection causes a severe hemorrhagic fever with a 50 percent fatality rate. Ebola, which is transmitted to people from wild animals and spreads in the human population through human-to-human transmission, first appeared in 1976 in what is now, Nzara, South Sudan, and in Yambuku, Democratic Republic of Congo. "Synthetic non-viral based DNA technology allows for rapid vac...
Vaccine, drug combo promising against HPV-related cancers

Vaccine, drug combo promising against HPV-related cancers

Health
Sept. 27 (UPI) -- Combining a tumor-specific vaccine with an immune checkpoint inhibitor shrank tumors in one third of patients with incurable cancer related to HPV, according to a phase II clinical trial. Participants were injected with the vaccine ISA101, which targets important peptides from a cancer-promoting HPV16 genotype of human papillomavirus, and nivolumab, a drug that blocks activation of PD-1 on T cells. The findings were published Thursday in the Journal of the Medical Association Oncology. "That encouraging response rate is about twice the rate produced by PD1 checkpoint inhibitors in previous clinical trials, so these results will lead to larger, randomized clinical trials of this combination," principal investigator Dr. Bonnie Glisson, a professor of thoracic/head and neck...
Deep brain stimulation promising for mild Alzheimer's patients older than 65

Deep brain stimulation promising for mild Alzheimer's patients older than 65

Health
June 19 (UPI) -- Alzheimer's patients older than 65 benefit the most benefit from deep brain stimulation, according to findings from a recent phase II clinical trial. Researchers at Toronto Western Hospital's Krembil Neuroscience Center for two years have been studying the stimulation of the fornix, a bundle of nerve fibers in the brain between the hippocampus and the hypothalamus. The findings, published this month in the Journal of Alzheimer's Disease, are an analysis of follow-up data during the second 12 months of a 2016 clinical trial. "We are encouraged by these findings as they continue to help us identify who will benefit most from DBS to treat Alzheimer's disease and learn more about this illness," Dr. Andres Lozano, a neurosurgeon at the Krembil Neuroscience Center and principa...