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Researchers engineer cough suppressant from yeast

Researchers engineer cough suppressant from yeast

Health
April 5 (UPI) -- Scientists have developed a way to bio-engineer from yeast a non-narcotic cough suppressant that is being tested for cancer treatment -- and a process that potentially can change the way medicines are made.Stanford researchers inserted 25 foreign genes, which came from the opium poppy, other plants and even rats, into the one-celled fungus. Their findings were published Monday in the Proceedings of the National Academy of Sciences.These enzymes are proteins that work together and can build complex substances.Noscapine is a non-narcotic cough suppressant that occurs naturally in opium poppies and is an ingredient in 14 cough medicines, including Coskap-N and Compress N."This is a technology that's going to change the way we manufacture essential medicines," Dr. Christina Sm...
New antifungal drug combats deadly microscopic yeast

New antifungal drug combats deadly microscopic yeast

Health
Jan. 12 (UPI) -- Scientists have discovered a novel drug compound capable of combating drug-resistant yeast strains.Microscopic yeast are a menace in hospitals. The fungi can grow in the nooks and crannies of medical equipment and hospital surfaces and can cause infections in patients with weakened immune systems. For some, an infection can prove fatal.Candida auris is one of the most problematic species, as it has developed resistance to multiple antifungal drugs.Current antifungals attack yeast by puncturing the cell membranes or by blocking sterol production. The new drug works by blocking vital proteins from attaching to the yeast cell wall. In doing so, the antifungal compound disrupts the yeast's growth process and prevents the formation of drug-resistant fungal communities.The compo...